排序方式: 共有84条查询结果,搜索用时 15 毫秒
31.
Traditionally, beamforming using fractional Fourier transform (FrFT) involves a trial-and-error based FrFT order selection which is impractical. A new numerical order selection scheme is presented based on fractional power spectra (FrFT moment) of the linear chirp signal. This method can adaptively determine the optimum FrFT order by maximizing the second-order central FrFT moment. This makes the desired chirp signal substantially concentrated whereas the noise is rejected considerably. This improves the mean square error minimization beamformer by reducing effectively the signal-noise cross terms due to the finite data length de-correlation operation. Simulation results show that the new method works well under a wide range of signal to noise ratio and signal to interference ratio. 相似文献
32.
Muhammad Mehmood Shahi Ahmad H. Ismail Ali MA. Abdul Amir AL-Mokaram R. Vikneswaran Sohail Ahm Amir Hamz Arshid Numan 《自然科学进展(英文版)》2017,27(5):582-587
Nitrogen-doped reduced graphene oxide(NrGO)sheets decorated with Co(OH)_2nanoflakes were prepared by a single-step hydrothermal process.The morphological and structural characterizations of as synthesized Nr GO@Co(OH)_2nanoflakes were performed by field emission scanning electron microscopy(FESEM),EDX-mapping and X-ray diffraction(XRD).Nr GO@Co(OH)_2nanoflakes modified glassy carbon electrode(GCE)was used for electrochemical sensing of dopamine in neutral medium.The nanocomposite modified electrode showed enhanced electrochemical sensing ability for the detection of dopamine and the limit of detection(Lo D)was found to be 0.201μM with a sensitivity value of 0.0286±0.002 m A m M~(-1).Interference studies revealed that Nr GO@Co(OH)_2─GCE endow excellent selectivity for DA detection even in the presence of higher concentration of common co-existing physiological interfering analytes.Additionally,proposed sensor demonstrated excellent performance in urine samples with promising reproducibility and stability. 相似文献
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Anjana Silva Ben Cristofori-Armstrong Lachlan D. Rash Wayne C. Hodgson Geoffrey K. Isbister 《Cellular and molecular life sciences : CMLS》2018,75(23):4465-4478
Snake venom α-neurotoxins potently inhibit rodent nicotinic acetylcholine receptors (nAChRs), but their activity on human receptors and their role in human paralysis from snakebite remain unclear. We demonstrate that two short-chain α-neurotoxins (SαNTx) functionally inhibit human muscle-type nAChR, but are markedly more reversible than against rat receptors. In contrast, two long-chain α-neurotoxins (LαNTx) show no species differences in potency or reversibility. Mutant studies identified two key residues accounting for this. Proteomic and clinical data suggest that paralysis in human snakebites is not associated with SαNTx, but with LαNTx, such as in cobras. Neuromuscular blockade produced by both subclasses of α-neurotoxins was reversed by antivenom in rat nerve–muscle preparations, supporting its effectiveness in human post-synaptic paralysis. 相似文献
35.
A discoidin domain receptor 1 knock-out mouse as a novel model for osteoarthritis of the temporomandibular joint 总被引:1,自引:1,他引:0
Boris Schminke Hayat Muhammad Christa Bode Boguslawa Sadowski Regina Gerter Nikolaus Gersdorff Ralf Bürgers Efrat Monsonego-Ornan Vicki Rosen Nicolai Miosge 《Cellular and molecular life sciences : CMLS》2014,71(6):1081-1096
Discoidin domain receptor 1 (DDR-1)-deficient mice exhibited a high incidence of osteoarthritis (OA) in the temporomandibular joint (TMJ) as early as 9 weeks of age. They showed typical histological signs of OA, including surface fissures, loss of proteoglycans, chondrocyte cluster formation, collagen type I upregulation, and atypical collagen fibril arrangements. Chondrocytes isolated from the TMJs of DDR-1-deficient mice maintained their osteoarthritic characteristics when placed in culture. They expressed high levels of runx-2 and collagen type I, as well as low levels of sox-9 and aggrecan. The expression of DDR-2, a key factor in OA, was increased. DDR-1-deficient chondrocytes from the TMJ were positively influenced towards chondrogenesis by a three-dimensional matrix combined with a runx-2 knockdown or stimulation with extracellular matrix components, such as nidogen-2. Therefore, the DDR-1 knock-out mouse can serve as a novel model for temporomandibular disorders, such as OA of the TMJ, and will help to develop new treatment options, particularly those involving tissue regeneration. 相似文献
36.
The world energy demand is increasing due to rapid growth in the global economy, industrialization, and urbanization. Pakistan is also confronted with increasing energy demand on one hand and is confronted with the challenge of energy demand-supply gap on the other hand. Since energy is the major driver for growth, it becomes important to investigate the trends of energy consumption in a country and the factors that are most affecting the changes in the use of energy. This particular study aims to investigate the use of energy by all the economic sectors of Pakistan during 2000–2012.The major contribution is the first time application of structural decomposition analysis(SDA) for energy usage along with using Input-Output data for the period of 2002–2012. The results show the fluctuation of the energy intensity of the sectors throughout the study period. Also, the overall effect of energy intensity is negative on energy consumption and it shows a negative contribution value of-80.90% for the study period. Furthermore, the focus on more energy-intensive products like cement,automobiles, iron, steel products and the increasing final demand of the economy contributes to the growth of energy consumption in Pakistan during 2000–2012. 相似文献
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Nicholas AK Khurshid M Désir J Carvalho OP Cox JJ Thornton G Kausar R Ansar M Ahmad W Verloes A Passemard S Misson JP Lindsay S Gergely F Dobyns WB Roberts E Abramowicz M Woods CG 《Nature genetics》2010,42(11):1010-1014
Autosomal recessive primary microcephaly (MCPH) is a disorder of neurodevelopment resulting in a small brain. We identified WDR62 as the second most common cause of MCPH after finding homozygous missense and frame-shifting mutations in seven MCPH families. In human cell lines, we found that WDR62 is a spindle pole protein, as are ASPM and STIL, the MCPH7 and MCHP7 proteins. Mutant WDR62 proteins failed to localize to the mitotic spindle pole. In human and mouse embryonic brain, we found that WDR62 expression was restricted to neural precursors undergoing mitosis. These data lend support to the hypothesis that the exquisite control of the cleavage furrow orientation in mammalian neural precursor cell mitosis, controlled in great part by the centrosomes and spindle poles, is critical both in causing MCPH when perturbed and, when modulated, generating the evolutionarily enlarged human brain. 相似文献
38.
Delneri D Hoyle DC Gkargkas K Cross EJ Rash B Zeef L Leong HS Davey HM Hayes A Kell DB Griffith GW Oliver SG 《Nature genetics》2008,40(1):113-117
Using competition experiments in continuous cultures grown in different nutrient environments (glucose limited, ammonium limited, phosphate limited and white grape juice), we identified genes that show haploinsufficiency phenotypes (reduced growth rate when hemizygous) or haploproficiency phenotypes (increased growth rate when hemizygous). Haploproficient genes (815, 1,194, 733 and 654 in glucose-limited, ammonium-limited, phosphate-limited and white grape juice environments, respectively) frequently show that phenotype in a specific environmental context. For instance, genes encoding components of the ubiquitination pathway or the proteasome show haploproficiency in nitrogen-limited conditions where protein conservation may be beneficial. Haploinsufficiency is more likely to be observed in all environments, as is the case with genes determining polar growth of the cell. Haploproficient genes seem randomly distributed in the genome, whereas haploinsufficient genes (685, 765, 1,277 and 217 in glucose-limited, ammonium-limited, phosphate-limited and white grape juice environments, respectively) are over-represented on chromosome III. This chromosome determines a yeast's mating type, and the concentration of haploinsufficient genes there may be a mechanism to prevent its loss. 相似文献
39.
Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair
Shimomura Y Wajid M Ishii Y Shapiro L Petukhova L Gordon D Christiano AM 《Nature genetics》2008,40(3):335-339
The genetic determinants of hair texture in humans are largely unknown. Several human syndromes exist in which woolly hair comprises a part of the phenotype; however, simple autosomal recessive inheritance of isolated woolly hair has only rarely been reported. To identify a gene involved in controlling hair texture, we performed genetic linkage analysis in six families of Pakistani origin with autosomal recessive woolly hair (ARWH; OMIM 278150). All six families showed linkage to chromosome 13q14.2-14.3 (Z = 17.97). In all cases, we discovered pathogenic mutations in P2RY5, which encodes a G protein-coupled receptor and is a nested gene residing within intron 17 of the retinoblastoma 1 (RB1) gene. P2RY5 is expressed in both Henle's and Huxley's layers of the inner root sheath of the hair follicle. Our findings indicate that disruption of P2RY5 underlies ARWH and, more broadly, uncover a new gene involved in determining hair texture in humans. 相似文献
40.
Muhammad USMAN Bingyu ZHANG 《系统科学与复杂性》2007,20(2):284-292
It has been observed in laboratory experiments that when nonlinear dispersive waves are forced periodically from one end of undisturbed stretch of the medium of propagation, the signal eventually becomes temporally periodic at each spatial point. The observation has been confirmed mathematically in the context of the damped Korteweg-de Vries (KdV) equation and the damped Benjamin-Bona-Mahony (BBM) equation. In this paper we intend to show the same results hold for the pure KdV equation (without the damping terms) posed on a finite domain. Consideration is given to the initial-boundary-value problem {ut+ux+uux+uxxx=0, u(x,0)=φ(x), 0〈x〈1, t〉0,u(0,t)=h(t), u(1,t) = 0, ux(1,t) = 0, t〉0.It is shown that if the boundary forcing h is periodic with small ampitude, then the small amplitude solution u of (*) becomes eventually time-periodic. Viewing (*) (without the initial condition) as an infinite-dimensional dynamical system in the Hilbert space L^2(0, 1), we also demonstrate that for a given periodic boundary forcing with small amplitude, the system (*) admits a (locally) unique limit cycle, or forced oscillation, which is locally exponentially stable. A list of open problems are included for the interested readers to conduct further investigations. 相似文献